Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria

BMC Microbiology

Emiko Saito¹  Michihiro Mutoh²  Hideki Ishikawa²  Noriko Shibuya³  Kenji Watanabe⁴  Yuta Tsunematsu⁴  Michio Sato⁴  Haruka Murakami⁵  Motohiko Miyachi⁵  Yuji Iwashita⁶  Haruhiko Sugimura⁶  Noriyuki Miyoshi⁷  Keiji Wakabayashi⁷  Jun Kunisawa⁸  Koji Hosomi⁸  Yuko Yoshikawa⁹ 

[1] Department of Human Nutrition, Tokyo Kasei Gakuin University;Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine;Department of Pediatrics, Maternal and Child Health Center, Aiiku Clinic;Department of Pharmaceutical Sciences, University of Shizuoka;Department of Physical Activity Research, Health and Nutrition (NIBIOHN), National Institutes of Biomedical Innovation;Department of Tumor Pathology, Hamamatsu University School of Medicine;Graduate School of Nutritional and Environmental Sciences, University of Shizuoka;Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, Laboratory of Gut Environmental System, Health and Nutrition (NIBIOHN), National Institutes of Biomedical Innovation;School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University;

关键词: Colibactin;    Natural product;    Escherichia coli;    Perinatal transmission;    Colorectal cancer;   

DOI  :  10.1186/s12866-021-02292-1

来源: DOAJ

【 摘 要 】

Abstract Background The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E. coli and the molecular mechanism of oncogenesis by colibactin may provide us with opportunities for early diagnosis or prevention of colorectal oncogenesis. While there have been major advances in the characterization of colibactin-positive E. coli and the toxin it produces, the infection route of the clb + strain remains poorly characterized. Results We examined infants and their treatments during and post-birth periods to examine potential transmission of colibactin-positive E. coli to infants. Here, analysis of fecal samples of infants over the first month of birth for the presence of a colibactin biosynthetic gene revealed that the bacterium may be transmitted from mother to infant through intimate contacts, such as natural childbirth and breastfeeding, but not through food intake. Conclusions Our finding suggests that transmission of colibactin-positive E. coli appears to be occurring at the very early stage of life of the newborn and hints at the possibility of developing early preventive measures against colorectal cancer.

【 授权许可】

Unknown