Recommedition for apllication and determination tumor markers of neuroendocrine system

Journal of Medical Biochemistry

Mirković Duško¹ 

[1] Institute of Medical Biochemistry, Clinical Centre of Serbia and School Pharmacy, University of Belgrade, Belgrade;

关键词: carcinoid;    carcinoma;    markers tumors;    neuroblastoma;    neuroendocrine;    pheochromocytoma;   

DOI  :  

来源: DOAJ

【 摘 要 】

Neuroendocrine tumors derive from neuroendocrine cells, which upon specific stimulation secrete stimulation secrete hormones regulating various bodily functions. We will discuss the group of neuroendocrine tumors which is consisted of: carcinoids, endocrine pancreatic tumors, neuroblastomas medullary thyroid carcinomas and pheochromocytomas. The tumors which derived from endocrine glads will be discused, as well as, we will pay attention on tumors which derived from so called "diffuse" neuroendocrine cell system of the gastrointestinal tract. In fact, this is the largest endocrine organ of the body. About 50 different neuroendocrine cell types of the gastrointestinal tract have been indentified. One of the currently recomended diagnostic approach to these lesions is the determination of characteristic bioactive amines and peptides of neuroendocrine activity, which is changed in neoplasms. The wide spectrum of clinical symptoms are associated with lesions of endocrine glands, and dispersed neuroendocrine system, results from their collective ability to secrete an extensive array of peptide hormones and bioactive amines, that differe according to the tumor type. The main aim of this disscusion is evaluation of these potential tumor markers, and proposing using some of those markers in our conditions.

【 授权许可】

Unknown