Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant

Nutrients

on behalf of the Groups¹  Anne Smits²  Maissa Rayyan²  Karel Allegaert²  Elisabeth Henrion³  Luc Cornette⁴  Myriam Van Winckel⁵  Ann De Guchtenaere⁶  Marc Raes⁷  Philippe Alliet⁷  Wim Arts⁸  An Bael⁹  Yvan Vandenplas⁹  Simon Fiesack^1,10  Kirsten Keiren^1,10  Bart Van Overmeire^1,11  Nathalie Kreins^1,12  Vinciane Vlieghe^1,13  Isabel George^1,14  Pierre Philippet^1,15  Nele De Mulder^1,16 

[1] ;Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium;Department of Neonatal Intensive Care, CHR Sambre et Meuse, 5000 Namur, Belgium;Department of Neonatology, AZ Sint-Jan, 8000 Brugge, Belgium;Department of Paediatrics, Ghent University Hospital, 9000 Ghent, Belgium;Department of Paediatrics, Ghent University, 9000 Ghent, Belgium;Department of Paediatrics, Jessa Hospital, 3500 Hasselt, Belgium;Department of Paediatrics, ZOL Genk, 3600 Genk, Belgium;Department of Pediatrics, ZNA Queen Paola Children’s Hospital, Faculty of Medicine UA, 2020 Antwerp, Belgium;Faculty of Medicine, KU Leuven, 3000 Leuven, Belgium;Kind en Gezin-Opgroeien, Vlaamse Overheid, 1000 Brussels, Belgium;Neonatal Intensive Care Unit, CHC MontLégia, 4000 Liège, Belgium;Neonatal Intensive Care Unit, Queen Fabiola Children’s University Hospital, Université Libre de Bruxelles, 1020 Bruxelles, Belgium;Neonatologie, AZ Groeninge, 8510 Kortrijk, Belgium;Pediatric Department, CHC MontLégia, 4000 Liège, Belgium;Vrije Universiteit Brussel (VUB), UZ Bussel, KidZ Health Castle, 1090 Brussels, Belgium;

关键词: vitamin K;    vitamin K deficiency bleeding;    term;    preterm;    prophylaxis;   

DOI  :  10.3390/nu13114109

来源: DOAJ

【 摘 要 】

Neonatal vitamin K prophylaxis is essential to prevent vitamin K deficiency bleeding (VKDB) with a clear benefit compared to placebo. Various routes (intramuscular (IM), oral, intravenous (IV)) and dosing regimens were explored. A literature review was conducted to compare vitamin K regimens on VKDB incidence. Simultaneously, information on practices was collected from Belgian pediatric and neonatal departments. Based on the review and these practices, a consensus was developed and voted on by all co-authors and heads of pediatric departments. Today, practices vary. In line with literature, the advised prophylactic regimen is 1 or 2 mg IM vitamin K once at birth. In the case of parental refusal, healthcare providers should inform parents of the slightly inferior alternative (2 mg oral vitamin K at birth, followed by 1 or 2 mg oral weekly for 3 months when breastfed). We recommend 1 mg IM in preterm <32 weeks, and the same alternative in the case of parental refusal. When IM is perceived impossible in preterm <32 weeks, 0.5 mg IV once is recommended, with a single additional IM 1 mg dose when IV lipids are discontinued. This recommendation is a step towards harmonizing vitamin K prophylaxis in all newborns.

【 授权许可】

Unknown