The Association Between Dietary Inflammatory Potential and Sex Hormones in Male Children and Adolescents Aged 6–19 Years

Frontiers in Endocrinology

Luojia Jiang³  Ruoxi Liao³  Zheng Qin³  Baihai Su³  Nuozhou Liu⁴ 

[1] Department of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China;Med+ Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University, Chengdu, China;Med-X Center for Materials, Sichuan University, Chengdu, China;West China School of Medicine, West China Hospital of Sichuan University, Chengdu, China;

关键词: dietary inflammatory index;    testosterone;    estradiol;    sex hormone;    NHANES;    cross-sectional study;   

DOI  :  10.3389/fendo.2021.722941

来源: DOAJ

【 摘 要 】

AimsThis study aimed to assess the relationship between dietary inflammatory index (DII) and sex hormones in male children and adolescents aged 6-19 years.MethodsWe obtained data from the 2013-2016 National Health and Nutrition Examination Survey (NHANES). Male participants aged 6-19 years old with the complete data of DII and sex hormones were included. Weighted multiple regression analysis and subgroup analysis were preformed to estimate the independent relationship between DII and sex hormones.ResultsA total of 1717 male participants with the average age of 13.02 ± 3.82 years were enrolled, of whom 41.3% (n=713) were children and 58.47% (n=1004) were adolescents. In children, mean DII was 0.18 ± 1.67, with scores ranging from -4.53 to 4.08. As for adolescents, the mean DII was 0.36 ± 1.98, mean total testosterone (TT) was 376.94 ± 206.69 ng/dl overall. A negative association between DII with TT and estradiol (E2) was observed (TT: β=-11.97, P=0.0006; E2: β=-0.45, P=0.0108) in male adolescent. Subgroup analysis and interaction test results indicated that this association was similar in male adolescents with different body mass index. No statistically significant association was observed in children.ConclusionsPro-inflammatory diet was associated with lower TT and E2 level in male adolescent, while no association with statistical significance between them was observed in male children. However, more studies are still needed to validate the causal relationship between DII and sex hormones.

【 授权许可】

Unknown