An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach

Heliyon

Sabiha Rahman Mim¹  Sadia Afrin²  Md. Rafat Tahsin³  Tanzia Islam Tithi³  Mokaddas Flora Ananta⁴  Shaila Kabir⁴  Arifa Sultana⁵  Ishrat Jahan⁶  Muhammad Shah Mohtasim Khan⁶  M. Sajjad Hussain⁶  Md. Shah Amran⁷  Abu Asad Chowdhury⁷  Fahima Aktar⁷  Mehnaz Ali⁷  Jakir Ahmed Chowdhury⁸ 

[1] Corresponding author.;Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh;Department of Pharmaceutical Sciences, North South University, Plot15, BlockB, Bashundhara R/A, Dhaka, 1229, Bangladesh;Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh;Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh;Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh;Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh;National Institute of Traumatology and Orthopaedic Rehabilitation (NITOR), Bangladesh;

关键词: Herbal remedy;    Anti-depressant;    Anti-diabetic;    Analgesic;    In-silico study;    T.arjuna;   

DOI  :  

来源: DOAJ

【 摘 要 】

Herbal remedies have been used in many cultures for decades to treat illnesses. These medicinal plants have been found to contain various phytochemical compounds that can help to cure mild to severe illnesses. The inadequacies of conventional medicines and their unusual side effects sparked a determined search for alternative natural therapeutic agents. Another reason for this hunt could be the availability and fewer side effects of natural products. T. arjuna is widely used in traditional medicine to alleviate various diseases like relieving pain, ameliorating diabetes, mitigating inflammation, and back-pedaling of depression. In this study, the ethanolic extract of T. arjuna possesses a promising effect on the animal model (p < 0.05/p < 0.01) as an antihyperglycemic, analgesic, anti-inflammatory, and antidepressant agent, but in a dose-dependent manner. The lower dose of T. arjuna was found to be capable of reversing the disturbed physiological state at a significant level (p < 0.05). However, a higher dose of T. arjuna exerts better therapeutic effects for those diseases. This animal study aims to evaluate the anti-diabetic, anti-depressant, and anti-inflammatory properties of T. arjuna compared to conventional marketed drugs. We will perform an in-silico study for active constituents of T. arjuna against their proposed targets and look for the molecular cascade on their claimed pharmacological properties. This study shows that different doses of T. arjuna bark extracts give similar therapeutic responses compared with established marketed drugs in managing hyperglycemia, stress-induced depression, and inflammation. Besides, our docking study reveals that flavonoids and triterpenoid active constituents of T. arjuna play an important role in its usefulness. This study, therefore, scientifically confirmed the traditional use of this medicinal plant in the management of several diseased conditions.

【 授权许可】

Unknown