Design, characterization of Resveratrol-Thermosensitive Hydrogel System (Res-THS) and evaluation of its anti-depressant effect via intranasal administration

Materials & Design

Feng Qiu¹  Xue-Jie Qi²  LiLi Duan³  Yu-Xin Wang³  Jin-Feng Zhou³  Meng-Li Tian³  Chen-Lin Wang³ 

[1] Tianjin Key Laboratory of Chinese Medicine Pharmacology, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China;Corresponding author at: School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, West District of Tuanbo New Town, Jinghai District, Tianjin 301617, PR China.;Tianjin Key Laboratory of Chinese Medicine Pharmacology, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China;

关键词: Anti-depressant;    Guanidine-chitosan;    Intranasal administration;    Resveratrol;    Thermosensitive hydrogel;   

DOI  :  

来源: DOAJ

【 摘 要 】

Thermosensitive Hydrogel System (THS) is a suitable candidate for targeted drug delivery, because of its intelligent response and controlled release. In this work, combination of guanidine-chitosan (GCS), β-glycerol phosphate disodium salt (β-GP) and hydroxypropyl-β-cyclodextrin (HP-β-CD) can successfully result in a novel THS by single factor and response surface method. The characterization of THS is detected with gelation temperature, FT-IR, SEM, in vitro release, rheology and biocompatibility. Resveratrol (Res) is selected as a model drug to evaluate the anti-depressant effects of THS loaded Res (Res-THS) via intranasal administration of chronic unpredictable mild stress (CUMS) rats. The results display that the Res-THS can increase concentration of neurotransmitter in rats’ brain tissue via intranasal administration, indicating the anti-depressant effect.

【 授权许可】

Unknown