Association of aortic valve calcification with carotid artery lesions and peripheral artery disease in patients with chronic kidney disease: a cross-sectional study

BMC Nephrology

Rina Imazu¹  Kimika Arakawa¹  Mitsuhiro Tominaga¹  Akiko Fukui²  Yuta Matsukuma²  Yuri Sonoda²  Susumu Tsuda²  Masaru Nakayama²  Ryota Yoshitomi²  Makiko Seki²  Toshiaki Nakano³  Takanari Kitazono³  Kazuhiko Tsuruya⁴  Yui Arita⁵ 

[1] Department of Internal Medicine, National Hospital Organization Kyushu Medical Center, Division of Hypertension and Clinical Research Institute;Department of Internal Medicine, National Hospital Organization Kyushu Medical Center, Division of Nephrology and Clinical Research Institute;Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University;Department of Nephrology, Nara Medical University;Division of Nephrology, Department of Internal Medicine, Yamaguchi Red Cross Hospital;

关键词: Aortic valve calcification;    Atherosclerosis;    Carotid artery plaque;    Chronic kidney disease;    Peripheral artery disease;   

DOI  :  10.1186/s12882-020-01864-z

来源: DOAJ

【 摘 要 】

Abstract Background Patients with chronic kidney disease (CKD) reportedly have a high prevalence of aortic valve calcification (AVC). In population-based studies, AVC is considered a manifestation of systemic atherosclerosis. The association of AVC with atherosclerotic lesions has not been fully investigated in predialysis patients. The present study was performed to determine whether carotid artery lesions and peripheral artery disease (PAD) are associated with AVC in patients with CKD not on dialysis. Methods In total, 749 patients were included in this cross-sectional study. AVC was evaluated using echocardiography. Carotid artery lesions including carotid artery plaque (CAP) and PAD were simultaneously examined in each patient. A logistic regression analysis was applied to determine the factors associated with AVC. Results AVC, CAP, and PAD were found in 201, 583, and 123 patients, respectively. In the multivariable analyses adjusted for covariates including the estimated glomerular filtration rate and makers of mineral metabolism (serum calcium, serum phosphorus, parathyroid hormone, 1,25-dihydroxyvitamin D, and fibroblast growth factor 23), AVC was significantly associated with the presence of CAP [odds ratio (OR), 3.37; 95% confidence interval (CI), 1.43–7.95], the presence of PAD (OR, 1.76; 95% CI, 1.10–2.81), the CAP score (per 1.0-point increase) (OR, 1.06; 95% CI, 1.02–1.11), and the ankle-brachial blood pressure index (per 0.1-point increase) (OR, 0.83; 95% CI, 0.72–0.95). Conclusions AVC was associated with atherosclerotic lesions independent of kidney function and mineral metabolism. We consider that this association between AVC and atherosclerosis might reflect the burden of shared atherosclerotic risk factors.

【 授权许可】

Unknown