Knee orthopedics as a template for the temporomandibular joint

Cell Reports Medicine

Benjamin J. Bielajew¹  Jerry C. Hu¹  Ryan P. Donahue¹  Kyriacos A. Athanasiou¹  M. Gabriela Espinosa¹  Mark E.K. Wong²  Nikolaos K. Paschos³  Dean Wang⁴  Boaz Arzi⁵  David C. Hatcher⁶ 

[1] Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA;Department of Oral and Maxillofacial Surgery, University of Texas School of Dentistry, Houston, TX, USA;Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;Department of Orthopaedic Surgery, University of California, Irvine Medical Center, Orange, CA, USA;Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA;Diagnostic Digital Imaging Center, Sacramento, CA, USA;

关键词: temporomandibular joint;    knee joint;    cartilage;    TMJ disc;    temporomandibular disorder;    osteoarthritis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Although the knee joint and temporomandibular joint (TMJ) experience similar incidence of cartilage ailments, the knee orthopedics field has greater funding and more effective end-stage treatment options. Translational research has resulted in the development of tissue-engineered products for knee cartilage repair, but the same is not true for TMJ cartilages. Here, we examine the anatomy and pathology of the joints, compare current treatments and products for cartilage afflictions, and explore ways to accelerate the TMJ field. We examine disparities, such as a 6-fold higher article count and 2,000-fold higher total joint replacement frequency in the knee compared to the TMJ, despite similarities in osteoarthritis incidence. Using knee orthopedics as a template, basic and translational research will drive the development and implementation of clinical products for the TMJ. With more funding opportunities, training programs, and federal guidance, millions of people afflicted with TMJ disorders could benefit from novel, life-changing therapeutics.

【 授权许可】

Unknown