Molecular Aspects of COVID-19 Differential Pathogenesis

Pathogens

Mukesh Kumar¹  HussinA. Rothan¹  StPatrick Reid²  Arpan Acharya³  SiddappaN. Byrareddy³ 

[1] Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA;Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA;Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Centre, Omaha, NE 68198, USA;

关键词: SARS-COV-2;    COVID-19;    differential pathogenesis;    comorbidity;    cardio-metabolic disease;   

DOI  :  10.3390/pathogens9070538

来源: DOAJ

【 摘 要 】

In the absence of therapeutic interventions, and a possible vaccine candidate, the spread of COVID-19 disease and associated fatalities are on the rise. The high mutation frequency in the genomic material of these viruses supports their ability to adapt to new environments, resulting in an efficient alteration in tissue tropism and host range. Therefore, the coronavirus’ health threats could be relevant for the long-term. The epidemiological data indicate that age, sex, and cardio-metabolic disease have a significant impact on the spread and severity of COVID-19. In this review, we highlight recent updates on the pathogenesis of SARS-CoV-2 among men and women, including children. We also discuss the role of the cellular receptors and coreceptors used by the virus to enter host cells on differential infection among men, women, and cardio-metabolic patients.

【 授权许可】

Unknown