Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A

Revista da Sociedade Brasileira de Medicina Tropical

关键词: Persistence;    Starvation;    Virulence;   

DOI  :  10.1590/0037-8682-0001-2018

来源: DOAJ

【 摘 要 】

AbstractINTRODUCTION: Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival.METHODS: Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host.RESULTS: Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture.CONCLUSIONS: These findings highlight the role of host stress in the virulence of S. epidermidis.

【 授权许可】

Unknown