Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

Nutrients

Angel Gil¹  Julio Plaza-Díaz¹  Francisco Javier Ruiz-Ojeda¹  Laura Maria Vilchez-Padial² 

[1] Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada 18071, Spain;Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Armilla, Granada 18016, Spain;

关键词: probiotics;    intestinal diseases;    anti-inflammatory effects;    inflammatory bowel diseases;   

DOI  :  10.3390/nu9060555

来源: DOAJ

【 摘 要 】

Probiotics and synbiotics are used to treat chronic diseases, principally due to their role in immune system modulation and the anti-inflammatory response. The present study reviewed the effects of probiotics and synbiotics on intestinal chronic diseases in in vitro, animal, and human studies, particularly in randomized clinical trials. The selected probiotics exhibit in vitro anti-inflammatory properties. Probiotic strains and cell-free supernatants reduced the expression of pro-inflammatory cytokines via action that is principally mediated by toll-like receptors. Probiotic administration improved the clinical symptoms, histological alterations, and mucus production in most of the evaluated animal studies, but some results suggest that caution should be taken when administering these agents in the relapse stages of IBD. In addition, no effects on chronic enteropathies were reported. Probiotic supplementation appears to be potentially well tolerated, effective, and safe in patients with IBD, in both CD and UC. Indeed, probiotics such as Bifidobacterium longum 536 improved the clinical symptoms in patients with mild to moderate active UC. Although it has been proposed that probiotics can provide benefits in certain conditions, the risks and benefits should be carefully assessed before initiating any therapy in patients with IBD. For this reason, further studies are required to understand the precise mechanism by which probiotics and synbiotics affect these diseases.

【 授权许可】

Unknown