Probiotics Can Cure Oral Aphthous-Like Ulcers in Inflammatory Bowel Disease Patients: A Review of the Literature and a Working Hypothesis

International Journal of Molecular Sciences

Angelo Leone¹  Fabio Bucchieri¹  Francesca Rappa¹  Dario Saguto¹  Giovanni Tomasello¹  Francesco Carini¹  Giuseppe Bonaventura¹  Federica Scalia¹  Francesco Cappello¹  Margherita Mazzola¹  Alberto Fucarino¹  Giuseppina Campisi²  Giovanna Giuliana²  Federica Canepa² 

[1] Department of Biomedicine and Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy;Department of Surgical, Oncological and Stomatological Disciplines, Sector of Oral Medicine, University of Palermo, 90127 Palermo, Italy;

关键词: microbiota;    muco-microbiotic layer;    dysbiosis;    inflammatory bowel diseases;    aphthous-like ulcers;    probiotics;   

DOI  :  10.3390/ijms20205026

来源: DOAJ

【 摘 要 】

Dysbiosis has been associated with the onset of several chronic autoimmune or inflammatory pathologies (e.g., inflammatory bowel diseases—IBD), because of its primary role in the establishment of a chronic inflammatory process leading to tissue damage. Inflammatory bowel diseases can even involve areas far away from the gut, such as the extraintestinal manifestations involving the oral cavity with the onset of aphthous-like ulcers (ALU). Studies carried out on animal models have shown that intestinal dysbiosis may be related to the development of autoimmune diseases, even if the mechanisms involved are not yet well known. The aim of this paper is to verify the hypothesis that in inflammatory bowel diseases patients, aphthous-like ulcers are the result of the concomitance of intestinal dysbiosis and other events, e.g., the microtraumas, occurring in the oral mucosa, and that ex adiuvantibus therapy with probiotics can be employed to modify the natural course of the aphthous-like ulcers.

【 授权许可】

Unknown