Effect of Pulsatility on the Transport of Thrombin in an Idealized Cerebral Aneurysm Geometry

Symmetry

Struan Hume¹  Malebogo N. Ngoepe¹  Arnaud G. Malan¹  Wei Hua Ho²  Jean-Marc Ilunga Tshimanga²  Patrick Geoghegan³ 

[1] Department of Mechanical Engineering, University of Cape Town, Rondebosch, Cape Town 7701, South Africa;Department of Mechanical Engineering, University of South Africa, Johannesburg 1709, South Africa;Department of Mechanical, Biomedical Engineering, Aston University, Birmingham B4 7ET, UK;

关键词: intracranial aneurysm;    thrombosis;    pulsatile flow;    CFD;    PIV;   

DOI  :  10.3390/sym14010133

来源: DOAJ

【 摘 要 】

Computational models of cerebral aneurysm thrombosis are designed for use in research and clinical applications. A steady flow assumption is applied in many of these models. To explore the accuracy of this assumption a pulsatile-flow thrombin-transport computational fluid dynamics (CFD) model, which uses a symmetrical idealized aneurysm geometry, was developed. First, a steady-flow computational model was developed and validated using data from an in vitro experiment, based on particle image velocimetry (PIV). The experimental data revealed an asymmetric flow pattern in the aneurysm. The validated computational model was subsequently altered to incorporate pulsatility, by applying a data-derived flow function at the inlet boundary. For both the steady and pulsatile computational models, a scalar function simulating thrombin generation was applied at the aneurysm wall. To determine the influence of pulsatility on thrombin transport, the outputs of the steady model were compared to the outputs of the pulsatile model. The comparison revealed that in the pulsatile case, an average of 10.2% less thrombin accumulates within the aneurysm than the steady case for any given time, due to periodic losses of a significant amount of thrombin-concentrated blood from the aneurysm into the parent vessel’s bloodstream. These findings demonstrate that pulsatility may change clotting outcomes in cerebral aneurysms.

【 授权许可】

Unknown