Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

Frontiers in Pharmacology

Irina Bakunina¹  Hua Yu²  Jian-ye Zhang³  Jaehong Han⁴  Alexander Dömling⁵  Zhuo-fen Deng⁶  Maria-José U Ferreira⁷ 

[1] Clinical Pharmacology, The State &NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China;Department of Pharmacy, University of Groningen, Groningen, Netherlands;G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia;Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR, China;;Key Laboratory of Molecular Target &Metalloenzyme Research Group and Department of Plant Science and Technology, Chung-Ang University, Anseong, Korea;

关键词: cancer;    chemotherapy;    multidrug resistance;    natural products;    diterpenoids;   

DOI  :  10.3389/fphar.2022.815603

来源: DOAJ

【 摘 要 】

Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.

【 授权许可】

Unknown