Evaluation of diuretic activity of Paspalidium flavidum in rats

Bangladesh Journal of Pharmacology

Sajid Bashir¹  Muhammad Akram¹  Abdul Qayyum Khan¹  Muhammad Naveed Mushtaq¹  Muhammad Nasir Hayat Malik¹  - Alamgeer¹  Muhammad Rashid²  Sadia Samreen³ 

[1] Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha;Department of Pharmacy, University of the Faisalabad;Department of Zoology, University of the Punjab, Lahore;

关键词: Diuretic;    Furosemide;    Paspalidium flavidum;    Phytochemical;    Rat;   

DOI  :  10.3329/bjp.v8i2.14243

来源: DOAJ

【 摘 要 】

This study was conducted to investigate the diuretic potential of aqueous methanolic extract of Paspalidium flavidum in rats. The extract at doses of 10, 30 50 and 100 mg/kg was administered intraperitoneally in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. Total urine volume and urinary excretion of electrolytes were measured. Preliminary phytochemical tests were also performed using standard procedures. The extract exhibiteda significant dose dependent diuretic effect at all the doses when compared to control group. Urinary excretion of sodium was significantly increased by the extract while a significant increase in potassium excretion was only observed at higher doses. Phytochemical analysis illustrated that the extract contained compounds such as alkaloids, saponins, tannins, flavonoids, cardiac glycosides and reducing sugars. It is conceivable therefore that the aqueous methanolic extract of P. flavidum contain certain biologically active compounds that might be responsible for the diuretic activity.

【 授权许可】

Unknown