The research status and prospect of Periostin in chronic kidney disease

Renal Failure

Yue Yu¹  Yuan-yuan Jia²  Hong -jun Li² 

[1] Department of Endocrinology and Metabolism, The Third Hospital of Jilin University;Department of Health Management Medical Center, The Third Hospital of Jilin University;

关键词: chronic kidney disease (ckd);    diagnosis;    extracellular matrix(ecm);    periostin;    therapeutic target;   

DOI  :  10.1080/0886022X.2020.1846562

来源: DOAJ

【 摘 要 】

The continuous accumulation of extracellular matrix will eventually lead to glomerular sclerosis, interstitial fibrosis, tubular atrophy and vascular sclerosis, which are involved in the progression of chronic kidney disease (CKD). If these processes can be discovered early and effective interventions given in time, the progression of kidney disease may be delayed. Therefore, exploring new biomarkers and therapeutic targets that can identify CKD at an early stage is urgently needed. In recent years, studies have shown that urine periostin may be used as a marker of early renal tubular injury. And in an animal model experiment of hypertensive nephropathy, periostin is involved in the progression of kidney injury and reflects its progression. Here we review the current progress on the role of periostin in pathologic pathways of kidney system to explore whether periostin is a potential therapeutic target for the treatment of CKD.

【 授权许可】

Unknown