Evidence of positively selected G6PD A‐ allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island

Molecular Genetics & Genomic Medicine

Xia Zhou¹  Wei‐Zhong Chen¹  Xiang‐Zhi Liu¹  Santiago‐m Monte‐Nguba²  Carlos Salas Ehapo²  Urbano Monsuy Eyi²  Hui‐Ying Huang³  Min Lin³  Guang‐Cai Zha³  Xue‐Yan Liang³  Li‐Yun Lin³  Yu‐Zhong Zheng³  Yan‐Bo Ma⁴  Dong‐De Xie⁵  Jiang‐Tao Chen⁵ 

[1] Department of Medical Laboratory Chaozhou People’s Hospital Affiliated to Shantou University Medical College Chaozhou Guangdong Province People’s Republic of China;Department of Medical Laboratory Malabo Regional Hospital Malabo Equatorial Guinea;School of Food Engineering and Biotechnology Hanshan Normal University Chaozhou Guangdong Province People’s Republic of China;School of Mathematics and Statistics Hanshan Normal University Chaozhou Guangdong Province People’s Republic of China;The Chinese Medical Aid Team to the Republic of Equatorial Guinea Guangzhou Guangdong Province People’s Republic of China;

关键词: EHH;    G6PD (A‐) deficiency;    malaria;    natural selection;   

DOI  :  10.1002/mgg3.1061

来源: DOAJ

【 摘 要 】

Abstract Background Glucose‐6‐phosphate dehydrogenase (G6PD) is an essential enzyme that protects red blood cells from oxidative damage. Although G6PD‐deficient alleles appear to confer a protective effect of malaria, the link with clinical protection against Plasmodium infection is conflicting. Methods A case–control study was conducted on Bioko Island, Equatorial Guinea and further genotyping analysis used to detect natural selection of the G6PD A‐ allele. Results Our results showed G6PD A‐ allele could significantly reduce the risk of Plasmodium falciparum infection in male individuals (adjusted odds ratio [AOR], 0.43; 95% confidence interval [CI], 0.20–0.93; p < .05) and homozygous female individuals (AOR, 0.11; 95% CI, 0.01–0.84; p < .05). Additionally, the parasite densities were significantly different in the individuals with different G6PD A‐ alleles and individual levels of G6PD enzyme activity. The pattern of linkage disequilibrium and results of the long‐range haplotype test revealed a strong selective signature in the region encompassing the G6PD A‐ allele over the past 6,250 years. The network of inferred haplotypes suggested a single origin of the G6PD A‐ allele in Africans. Conclusion Our findings demonstrate that glucose‐6‐phosphate dehydrogenase (G6PD) A‐ allele could reduce the risk of P. falciparum infection in the African population and indicate that malaria has a recent positive selection on G6PD A‐ allele.

【 授权许可】

Unknown