Effect of sitagliptin on blood glucose control in patients with type 2 diabetes mellitus who are treatment naive or poorly responsive to existing antidiabetic drugs: the JAMP study

BMC Endocrine Disorders

for the JAMP Study Investigators¹  Naotake Hashimoto²  Noriko Ujihara³  Hiroshi Sakura⁴  Hideo Nunome⁵  Osamu Tomonaga⁶  Sumiko Hasumi⁷  Hiroshi Ohashi⁸  Kazuo Sasamoto⁹  Tadasu Kasahara^1,10  Masashi Honda^1,11  Yasuhiko Iwamoto^1,12 

[1] ;Department of Diabetes, Endocrine and Metabolic Diseases, Tokyo Women’s Medical University Yachiyo Medical Center;Department of Medicine, Diabetes Center, Institute of Geriatrics, Tokyo Women’s Medical University;Department of Medicine, Medical Center East, Tokyo Women’s Medical University School of Medicine;Diabetes Center, Edogawa Hospital, Medical Plaza Shinozaki;Diabetes and Lifestyle Center, Tomonaga Clinic;Internal Medicine, Nishiyamado-Keiwa Hospital;Internal Medicine, Oyama East Clinic;Internal Medicine, Suzuki Clinic;Josai Hospital;Nishikawa Clinic;The Institute for Adult Diseases, Asahi Life Foundation;

关键词: Sitagliptin;    Diabetes mellitus;    DPP-4 inhibitor;    HbA1c;    Glimepiride;   

DOI  :  10.1186/s12902-016-0149-z

来源: DOAJ

【 摘 要 】

Abstract Background To investigate the ameliorating effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood glucose control in patients with type 2 diabetes mellitus who were previously untreated with or who have a poor responsive to existing antidiabetic drugs. Methods Sitagliptin (50 mg/day) was added on to the pre-existing therapy for type 2 diabetes and changes in the glycated hemoglobin (HbA1c) level after 3 months of treatment were compared with the baseline and performed exploratory analysis. Results HbA1c levels were significantly decreased after 1 month of treatment compared to baseline, with a mean change in HbA1c level from baseline of −0.73% (range, −0.80 to −0.67) in the entire study population at 3 months. Patients who received a medium dose of glimepiride showed the least improvement in HbA1c levels. The percentage of patients who achieved an HbA1c level of <7.0% significantly increased after 1 month of treatment, reaching 53.1% at 3 months. The percentage of patients who achieved a fasting blood glucose level of <130 mg/dL significantly increased after 1 month of treatment, reaching 50.9% at 3 months. Conclusions Sitagliptin improved the HbA1c level and rate of achieving the target control levels in patients with type 2 diabetes mellitus who were previously untreated with, or poorly responsive to, existing antidiabetic drugs. Thus, sitagliptin is expected to be useful in this patient group. However, the additional administration of sitagliptin in patients treated with medium-dose glimepiride only slightly improved blood glucose control when corrected for baseline HbA1c level.

【 授权许可】

Unknown