Prediction of microbial communities for urban metagenomics using neural network approach

Human Genomics

Chelsea J.-T. Ju¹  Wei Wang¹  Jyun-Yu Jiang¹  Guangyu Zhou¹ 

[1] Department of Computer Science, University of California;

关键词: Urban metagenomics;    Multi-label classification;    Neural network;   

DOI  :  10.1186/s40246-019-0224-4

来源: DOAJ

【 摘 要 】

Abstract Background Microbes are greatly associated with human health and disease, especially in densely populated cities. It is essential to understand the microbial ecosystem in an urban environment for cities to monitor the transmission of infectious diseases and detect potentially urgent threats. To achieve this goal, the DNA sample collection and analysis have been conducted at subway stations in major cities. However, city-scale sampling with the fine-grained geo-spatial resolution is expensive and laborious. In this paper, we introduce MetaMLAnn, a neural network based approach to infer microbial communities at unsampled locations given information reflecting different factors, including subway line networks, sampling material types, and microbial composition patterns. Results We evaluate the effectiveness of MetaMLAnn based on the public metagenomics dataset collected from multiple locations in the New York and Boston subway systems. The experimental results suggest that MetaMLAnn consistently performs better than other five conventional classifiers under different taxonomic ranks. At genus level, MetaMLAnn can achieve F1 scores of 0.63 and 0.72 on the New York and the Boston datasets, respectively. Conclusions By exploiting heterogeneous features, MetaMLAnn captures the hidden interactions between microbial compositions and the urban environment, which enables precise predictions of microbial communities at unmeasured locations.

【 授权许可】

Unknown