Synthesis of some 3,5-diarylisoxazoline derivatives in ionic liquids media

Journal of the Serbian Chemical Society

关键词: isoxazoline;    cyclization reaction;    ionic liquids;    butylmethylimidazolium bromide;    multi-component reactions;    biological activities;   

DOI  :  10.2298/JSC110831001S

来源: DOAJ

【 摘 要 】

Biologically active isoxazoline derivatives were efficiently synthesized inexcellent yields and in less reaction time using mild, effective andenvironmentally friendly butylmethylimidazolium bromide as solvent andcatalyst. By use of this catalyst isoxazoline derivatives are produced viacyclization reaction of chalcone and hydroxylamine hydrochloride in ionicliquids media. The separation of the product was facile and the catalystcould be separated and recycled. Our method is very quick, safe and avoidsthe use of hazardous and expensive reagents and solvents.

【 授权许可】

Unknown