Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera

Molecules

Zhong-Tao Ding¹  Huai Xiao¹  Tian-Peng Yin¹  Le Cai¹  Jian-Wei Dong¹  Xiu-Mei Wu²  Jian-Rong Luo²  Qing Luo² 

[1] Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali 671000, China;

关键词: Blaps rynchopetera;    chemical constituents;    phenolic;    rynchopeterines A–E;    antioxidant;    anti-tumor;   

DOI  :  10.3390/molecules22081301

来源: DOAJ

【 摘 要 】

Five new phenolic compounds rynchopeterines A–E (1–5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A–E (1–4) exhibited significant antioxidant activities with IC50 values of 7.67–12.3 μg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549.

【 授权许可】

Unknown