Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing

Pharmaceutics

GuilhermeArthur Longhitano¹  RogérioLeone Buchaim²  KarinaTorres Pomini²  Emiliode Castro Miguel³  MarceloRodrigues da Cunha⁴  TiagoNeves Andrade⁴  Amilton Iatecola⁴  LuizHenrique Martinez Antunes⁵  Miloslav Béreš⁵  AndréLuiz Jardini⁵  JeffersonAparecido Dias⁶  DanielaVieira Buchaim⁶  DanieleRaineri Mesquita Serva Spressão⁶  GuineaBrasil Camargo Cardoso⁷  Marcílio Felix⁸  CarlosSalles Lambert⁹ 

[1] Center for Information Technology Renato Archer (CTI), Campinas 13069-901, São Paulo, Brazil;Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, São Paulo, Brazil;Department of Metallurgical and Materials Engineering, Federal University of Ceará, Fortaleza 60440-554, Ceará, Brazil;Faculty of Medicine of Jundiaí, Jundiaí 13202-550, São Paulo, Brazil;National Institute of Biofabrication (INCT-BIOFABRIS), Campinas 13083-852, São Paulo, Brazil;Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, São Paulo, Brazil;School of Mechanical Engineering, University of Campinas (UNICAMP), Campinas 13083-860, São Paulo, Brazil;Veterinary Medicine School, University of Marilia (UNIMAR), Marília 17525-902, São Paulo, Brazil;“Gleb Wataghin” Institute of Physics, University of Campinas (UNICAMP), Campinas 13083-859, São Paulo, Brazil;

关键词: additive manufacturing;    plasma immersion ion implantation;    Co-Cr-Mo alloy;    osseointegration;    orthopedic implants;   

DOI  :  10.3390/pharmaceutics13050724

来源: DOAJ

【 摘 要 】

Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive manufacturing (AM) limits the efficiency of mechanical-based surface modification techniques. Therefore, plasma immersion ion implantation (PIII) is the best alternative, creating nanotopography even in complex structures. In the present study, we report the osseointegration results in three conditions of the additively manufactured Co-Cr-Mo alloy: (i) as-built, (ii) after PIII, and (iii) coated with titanium (Ti) followed by PIII. The metallic samples were designed with a solid half and a porous half to observe the bone ingrowth in different surfaces. Our results revealed that all conditions presented cortical bone formation. The titanium-coated sample exhibited the best biomechanical results, which was attributed to the higher bone ingrowth percentage with almost all medullary canals filled with neoformed bone and the pores of the implant filled and surrounded by bone ingrowth. It was concluded that the metal alloys produced for AM are biocompatible and stimulate bone neoformation, especially when the Co-28Cr-6Mo alloy with a Ti-coated surface, nanostructured and anodized by PIII is used, whose technology has been shown to increase the osseointegration capacity of this implant.

【 授权许可】

Unknown