Central pontine myelinolysis in the presence of SARS-CoV-2 infection (clinical observations)

Nevrologiâ, Nejropsihiatriâ, Psihosomatika

A. A. Kovalenko¹  E. B. Nadbitova¹  A. V. Klimanov¹  Yu. M. Shor¹  O. N. Voskresenskaya¹  V. V. Grinyuk¹ 

[1] A.Ya. Kozhevnikov Clinic of Nervous System Diseases, University hospital №3, Department of Nervous System Diseases and Neurosurgery, N.V. Sklifosovsky Clinical Medicine Institute, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia;

关键词: central pontine myelinolysis;    hyponatremia;    sodium deficiency;    osmotic demyelinating syndrome;   

DOI  :  10.14412/2074-2711-2021-2-91-96

来源: DOAJ

【 摘 要 】

Osmotic demyelinating syndrome (ODS) is a severe complication that occurs due to rapid correction of hyponatremia. Central  pontine myelinolysis (CPM), in which a focus of demyelination  occurs in the pontine region, and extrapontine myelinolysis (EPM),  in which foci of demyelination appear in the white matter of the  cerebral hemispheres, can be distinguished as a part of this  syndrome. We describe two clinical cases of CPM that developed due to hyponatremia and hypokalemia in patients with SARS-CoV-2 infection (COVID-19). Differential diagnosis included acute  disseminated encephalomyelitis, infectious encephalitis, and brain  tumor. In both cases, a significant recovery of the lost functions was noted. The pathogenetic mechanisms of CPM development in  patients with COVID-19 are discussed. ODS development in COVID- 19 necessitates strict control and correction of electrolyte  disturbances in this category of patients in accordance with existing  recommendations, which can reduce the risk of CPM.

【 授权许可】

Unknown