Tremor and Other Hyperkinetic Movements | |
Dramatic Response to Pramipexole in Delayed-Onset Parkinsonism from Osmotic Demyelinating Syndrome | |
article | |
Steve C. Han1  Linn Katus2  Steven Frucht1  | |
[1] Department of Neurology, NYU Grossman School of Medicine;Department of Neurology, New York-Presbyterian Hospital/Columbia University | |
关键词: Parkinsonism; extrapyramidal symptoms; osmotic demyelinating syndrome; | |
DOI : 10.5334/tohm.66 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Ubiquity Press | |
【 摘 要 】
Background: Delayed parkinsonism and dystonia are recognized phenomena in osmotic demyelinating syndrome (ODS). Dopamine receptor agonists and levodopa have been reported to benefit select patients. Case report: We report a patient with ODS with severe pseudobulbar deficits, parkinsonism and dystonia, poorly responsive to levodopa, who experienced a remarkable improvement with pramipexole. Discussion: A marked response to pramipexole with lack of response to levodopa suggests a pre-synaptic source for his deficits coupled with injuries to non-nigral compensatory structures. Highlights: This case highlights a dramatic response of osmotic demyelination-induced parkinsonism/dystonia to pramipexole. A lack of response to levodopa suggests deficits in the pre-synaptic nigral as well as non-nigral compensatory structures.
【 授权许可】
CC BY
【 预 览 】
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RO202106150001342ZK.pdf | 1181KB | download |