Dramatic Response to Pramipexole in Delayed-Onset Parkinsonism from Osmotic Demyelinating Syndrome

Tremor and Other Hyperkinetic Movements

article

Steve C. Han¹  Linn Katus²  Steven Frucht¹ 

[1] Department of Neurology, NYU Grossman School of Medicine;Department of Neurology, New York-Presbyterian Hospital/Columbia University

关键词: Parkinsonism;    extrapyramidal symptoms;    osmotic demyelinating syndrome;   

DOI  :  10.5334/tohm.66

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Background: Delayed parkinsonism and dystonia are recognized phenomena in osmotic demyelinating syndrome (ODS). Dopamine receptor agonists and levodopa have been reported to benefit select patients. Case report: We report a patient with ODS with severe pseudobulbar deficits, parkinsonism and dystonia, poorly responsive to levodopa, who experienced a remarkable improvement with pramipexole. Discussion: A marked response to pramipexole with lack of response to levodopa suggests a pre-synaptic source for his deficits coupled with injuries to non-nigral compensatory structures. Highlights: This case highlights a dramatic response of osmotic demyelination-induced parkinsonism/dystonia to pramipexole. A lack of response to levodopa suggests deficits in the pre-synaptic nigral as well as non-nigral compensatory structures.

【 授权许可】

CC BY