Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway

Frontiers in Oncology

Yingxin Yang¹  Yecheng Jin¹  Ling Zhang²  Yang Jiao³  Jiayan Zhou⁴  Mingxu Song⁶  Jialiang Zhou⁶  Jiwei Zhang⁷ 

[1] Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China;College of Life Science, Zhejiang Chinese Medical University, Hangzhou, China;College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China;Department of Statistics, Eberly College of Science, The Pennsylvania State University, University Park, PA, United States;Department of Veterinary and Biomedical Sciences, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA, United States;The Affiliated Hospital of Jiangnan University, Wuxi, China;The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China;

关键词: colorectal cancer;    TDRKH-AS1;    Wnt signal pathway;    β-catenin;    TCGA;    RNA sequencing analysis;   

DOI  :  10.3389/fonc.2020.00639

来源: DOAJ

【 摘 要 】

Colorectal cancer (CRC) is a common cancer worldwide, with a lower 5-years survival rate. Recently, long non-coding RNAs (lncRNAs) have been well-studied as the oncogenes or the tumor suppressors in multiple malignancies, including CRC. However, their biological functions and potential mechanisms in human cancer remain unclear. Here, we evaluated the expression of TDRKH-AS1 in CRC tissues and identified its potential targets. We found that TDRKH-AS1 is upregulated in majority of CRC patients, which is also significantly correlated with their malignant characteristics and their dismal prognoses. The high expression of TDRKH-AS1 can promote cancer cell proliferation substantially and invasion based on in vitro experiments. We also recognized that the TDRKH-AS1 targets the β-catenin in the Wnt signaling pathway to exert its carcinogenic activity. TDRKH-AS1 could serve as a promising prognostic predictor and a potential therapeutic target for further early diagnoses and treatments via a non-invasive method.

【 授权许可】

Unknown