Subsets of CD1c+ DCs: Dendritic Cell Versus Monocyte Lineage

Frontiers in Immunology

Loems Ziegler-Heitbrock¹  Marc Dalod²  I. Jolanda M. de Vries⁴  Thomas P. Hofer⁷  Lukas Heger⁸  Diana Dudziak⁹  Venetia Bigley^1,10 

[1] 0Monocytomics Research, Munich, Germany;Aix Marseille Univ, CNRS, INSERM, CIML, Centre d’Immunologie de Marseille-Luminy, Marseille, France;Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg (CCC ER-EMN), Erlangen, Germany;Department of Medical Oncology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, Netherlands;Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, Netherlands;Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany;Immunoanalytics-Tissue Control of Immunocytes and Core Facility, Helmholtz Centre Munich, Munich, Germany;Laboratory of Dendritic Cell Biology, Department of Dermatology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany;Medical Immunology Campus Erlangen, Erlangen, Germany;Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom;

关键词: DC2;    CD1c;    CD172;    CD301;    CD14;    dendritic cells;   

DOI  :  10.3389/fimmu.2020.559166

来源: DOAJ

【 摘 要 】

Currently three bona fide dendritic cell (DC) types are distinguished in human blood. Herein we focus on type 2 DCs (DC2s) and compare the three defining markers CD1c, CD172, and CD301. When using CD1c to define DC2s, a CD14+ and a CD14− subset can be detected. The CD14+ subset shares features with monocytes, and this includes substantially higher expression levels for CD64, CD115, CD163, and S100A8/9. We review the current knowledge of these CD1c+CD14+ cells as compared to the CD1c+CD14− cells with respect to phenotype, function, transcriptomics, and ontogeny. Here, we discuss informative mutations, which suggest that two populations have different developmental requirements. In addition, we cover subsets of CD11c+CD8− DC2s in the mouse, where CLEC12A+ESAMlow cells, as compared to the CLEC12A−ESAMhigh subset, also express higher levels of monocyte-associated markers CD14, CD3, and CD115. Finally, we summarize, for both man and mouse, the data on lower antigen presentation and higher cytokine production in the monocyte-marker expressing DC2 subset, which demonstrate that the DC2 subsets are also functionally distinct.

【 授权许可】

Unknown