Herpesvirus Antibodies, Vitamin D and Short-Chain Fatty Acids: Their Correlation with Cell Subsets in Multiple Sclerosis Patients and Healthy Controls

Cells

Rafael Arroyo¹  Hector Estevez²  Estefania Garcia-Calvo²  JoseLuis Luque Garcia²  Roberto Alvarez-Lafuente³  Isabel Ortega-Madueño³  MariaAngel Garcia-Martinez³  MariaInmaculada Dominguez-Mozo³  Silvia Perez-Perez³  MariaJosefa Torrejon⁴  Noelia Villarrubia⁵  LuisaMaria Villar⁵  JoseIgnacio Fernandez-Velasco⁵  Lucienne Costa-Frossard⁶ 

[1] Departamento de Neurología, Hospital Universitario Quironsalud Madrid, Red Española de Esclerosis Múltiple (REEM), 28040 Madrid, Spain;Department of Analytical Chemistry, Faculty of Chemical Sciences, Universidad Complutense de Madrid, 28040 Madrid, Spain;Grupo de Investigación de Factores Ambientales en Enfermedades Degenerativas, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)/Red Española de Esclerosis Múltiple (REEM), 28040 Madrid, Spain;Servicio de Análisis Clínicos, Hospital Clínico San Carlos, 28040 Madrid, Spain;Servicio de Inmunología, Hospital Universitario Ramón y Cajal/Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Red Española de Esclerosis Múltiple (REEM), 28040 Madrid, Spain;Servicio de Neurología, Hospital Universitario Ramón y Cajal/Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Red Española de Esclerosis Múltiple (REEM), 28040 Madrid, Spain;

关键词: human herpesvirus;    vitamin D;    multiple sclerosis;    ELISA;    flow-cytometry;   

DOI  :  10.3390/cells10010119

来源: DOAJ

【 摘 要 】

Although the etiology of multiple sclerosis (MS) is still unknown, it is commonly accepted that environmental factors could contribute to the disease. The objective of this study was to analyze the humoral response to Epstein-Barr virus, human herpesvirus 6A/B and cytomegalovirus, and the levels of 25-hydroxyvitamin D (25(OH)D) and the three main short-chain fatty acids (SCFA), propionate (PA), butyrate (BA) and acetate (AA), in MS patients and healthy controls (HC) to understand how they could contribute to the pathogenesis of the disease. With this purpose, we analyzed the correlations among them and with different clinical variables and a wide panel of cell subsets. We found statistically significant differences for most of the environmental factors analyzed when we compared MS patients and HC, supporting their possible involvement in the disease. The strongest correlations with the clinical variables and the cell subsets analyzed were found for 25(OH)D and SCFAs levels. A correlation was also found between 25(OH)D and PA/AA ratio, and the interaction between these factors negatively correlated with interleukin 17 (IL-17)-producing CD4+ and CD8+ T cells in untreated MS patients. Therapies that simultaneously increase vitamin D levels and modify the proportion of SCFA could be evaluated in the future.

【 授权许可】

Unknown