Vitamin D as an Immunomodulator: Risks with Deficiencies and Benefits of Supplementation

Healthcare

Jason R. Goldsmith¹  Samir Samman¹ 

[1] Department of Internal Medicine, University of Michigan, 3116G Taubman Center, SPC 5368, Ann Arbor, MI 48109, USA; E-Mail

关键词: vitamin D;    immune function;    immunomodulator;    inflammatory bowel diseases;    multiple sclerosis;    rheumatoid arthritis;    Treg;   

DOI  :  10.3390/healthcare3020219

来源: mdpi

【 摘 要 】

Vitamin D refers to a class of fat-soluble secosteroids often associated with their role in absorption and metabolism of minerals such as calcium and phosphate. In recent years, our understanding of vitamin D has expanded to include its role in modulating the immune system. Of particular focus are the effects of vitamin D deficiency and supplementation on patients suffering from disorders due to dysregulation of the immune system. In patients with multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease, deficiencies in vitamin D have been associated with an increased risk of disease activity. In this review, we will look at the current state of research in regards to the relationship between vitamin D and immune-dysregulation. We will focus on both the risks associated with vitamin D deficiency as well as the benefits of vitamin D supplementation.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.