Long Non-Coding RNAs as Master Regulatorsin Cardiovascular Diseases

International Journal of Molecular Sciences

Krystal Archer¹  Alec Davila¹  Yaoliang Tang¹  Zuzana Broskova²  Jian-peng Teoh²  Ahmed S. Bayoumi²  Huabo Su²  Il-man Kim² 

[1] Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta,GA 30912, USA;Vascular Biology Center, Medical College of Georgia, Georgia Regents University, Augusta,GA 30912, USA;

关键词: chromatin;    epigenetic regulation;    gene regulation;    heart disease;    non-coding RNAs;   

DOI  :  10.3390/ijms161023651

来源: DOAJ

【 摘 要 】

Cardiovascular disease is the leading cause of death in the United States, accounting for nearly one in every seven deaths. Over the last decade, various targeted therapeutics have been introduced, but there has been no corresponding improvement in patient survival. Since the mortality rate of cardiovascular disease has not been significantly decreased, efforts have been made to understand the link between heart disease and novel therapeutic targets such as non-coding RNAs. Among multiple non-coding RNAs, long non-coding RNA (lncRNA) has emerged as a novel therapeutic in cardiovascular medicine. LncRNAs are endogenous RNAs that contain over 200 nucleotides and regulate gene expression. Recent studies suggest critical roles of lncRNAs in modulating the initiation and progression of cardiovascular diseases. For example, aberrant lncRNA expression has been associated with the pathogenesis of ischemic heart failure. In this article, we present a synopsis of recent discoveries that link the roles and molecular interactions of lncRNAs to cardiovascular diseases. Moreover, we describe the prevalence of circulating lncRNAs and assess their potential utilities as biomarkers for diagnosis and prognosis of heart disease.

【 授权许可】

Unknown