Endoplasmic reticulum: a focal point of Zika virus infection

Journal of Biomedical Science

Ahmad Suhail Khazali¹  Nurshamimi Nor Rashid¹  Muhammad Izzuddin Mohd Ropidi¹  Rohana Yusof¹ 

[1] Department of Molecular Medicine, Faculty of Medicine, University of Malaya;

关键词: Zika virus;    Endoplasmic reticulum;    Unfolded protein response;    Stress granules;    Reticulophagy;    Paraptosis;   

DOI  :  10.1186/s12929-020-0618-6

来源: DOAJ

【 摘 要 】

Abstract Zika virus (ZIKV) belongs to the Flavivirus genus of the Flaviviridae family. It is an arbovirus that can cause congenital abnormalities and is sexually transmissible. A series of outbreaks accompanied by unexpected severe clinical complications have captured medical attention to further characterize the clinical features of congenital ZIKV syndrome and its underlying pathophysiological mechanisms. Endoplasmic reticulum (ER) and ER-related proteins are essential in ZIKV genome replication. This review highlights the subcellular localization of ZIKV to the ER and ZIKV modulation on the architecture of the ER. This review also discusses ZIKV interaction with ER proteins such as signal peptidase complex subunit 1 (SPCS1), ER membrane complex (EMC) subunits, and ER translocon for viral replication. Furthermore, the review covers several important resulting effects of ZIKV infection to the ER and cellular processes including ER stress, reticulophagy, and paraptosis-like death. Pharmacological targeting of ZIKV-affected ER-resident proteins and ER-associated components demonstrate promising signs of combating ZIKV infection and rescuing host organisms from severe neurologic sequelae.

【 授权许可】

Unknown