Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials

Molecules

Veronica Folliero¹  Massimiliano Galdiero¹  Gianluigi Franci¹  Annarita Falanga²  Stefania Galdiero³  Francisco Javier de la Mata⁴  Rafael Gómez⁴  Sandra García-Gallego⁴ 

[1] Department of Experimental Medicine, II University of Naples, Via Costantinopoli 16, 80138 Naples, Italy;Department of Pharmacy, University of Naples “Federico II”, Via Mezzocannone 16, 80134 Napoli, Italy;Interuniversity Research Centre on Bioactive Peptides (CiRPEB), University of Naples “Federico II”, Via Mezzocannone 16, 80134 Naples, Italy;Organic and Inorganic Chemistry Department, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain;

关键词: dendrimers;    structure;    preparation;    delivery;    antimicrobial;    antibacterial;    antiviral;    antiparasitic;   

DOI  :  10.3390/molecules22101581

来源: DOAJ

【 摘 要 】

In recent years innovative nanostructures are attracting increasing interest and, among them, dendrimers have shown several fields of application. Dendrimers can be designed and modified in plentiful ways giving rise to hundreds of different molecules with specific characteristics and functionalities. Biomedicine is probably the field where these molecules find extraordinary applicability, and this is probably due to their multi-valency and to the fact that several other chemicals can be coupled to them to obtain desired compounds. In this review we will describe the different production strategies and the tools and technologies for the study of their characteristics. Finally, we provide a panoramic overview of their applications to meet biomedical needs, especially their use as novel antimicrobials.

【 授权许可】

Unknown