Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

Medicines

Mohammed Monzur Morshed¹  Muhammad Shahdaat Bin Sayeed²  Tasnuva Sharmin³  Selim Muhammad Rezaul Karim⁴ 

[1] Department of Biochemistry and Molecular, Biology, University of Dhaka, Dhaka-1000, Bangladesh;Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka-1000, Bangladesh;Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh;Department of Pharmacy, Daffodil International University, Dhaka-1207, Bangladesh;

关键词: beta-sitosterol;    orphan phytosterol;    characterization;    therapeutic potential;    drug delivery;   

DOI  :  10.3390/medicines3040029

来源: DOAJ

【 摘 要 】

Beta-sitosterol (BS) is a phytosterol, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. To compile the sources, physical and chemical properties, spectral and chromatographic analytical methods, synthesis, systemic effects, pharmacokinetics, therapeutic potentials, toxicity, drug delivery and finally, to suggest future research with BS, classical as well as on-line literature were studied. Classical literature includes classical books on ethnomedicine and phytochemistry, and the electronic search included Pubmed, SciFinder, Scopus, the Web of Science, Google Scholar, and others. BS could be obtained from different plants, but the total biosynthetic pathway, as well as its exact physiological and structural function in plants, have not been fully understood. Different pharmacological effects have been studied, but most of the mechanisms of action have not been studied in detail. Clinical trials with BS have shown beneficial effects in different diseases, but long-term study results are not available. These have contributed to its current status as an “orphan phytosterol”. Therefore, extensive research regarding its effect at cellular and molecular level in humans as well as addressing the claims made by commercial manufacturers such as the cholesterol lowering ability, immunological activity etc. are highly recommended.

【 授权许可】

Unknown