Chemical constiuents from Richardia grandiflora (Cham. & Schltdl.) Steud. (Rubiaceae)

Revista Brasileira de Farmacognosia

Anna Cláudia De A. Tomaz¹  Raquel Bezerra S. S. Nogueira¹  Danielle Serafim Pinto¹  Maria De Fátima Agra¹  Maria De Fátima V. De Souza¹  Emídio V. Leitão Da-cunha¹ 

[1] ,Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica João Pessoa PB ,Brazil

关键词: Richardia grandiflora;    Rubiaceae;    beta-sitosterol;    stigmasterol;    o-hydroxy-benzoic acid;    m-methoxy-p-hydroxy-benzoic acid;    phaeophitin A;    Richardia grandiflora;    Rubiaceae;    beta-sitosterol;    estigmasterol;    ácido o-hidroxibenzóico;    ácido m-metoxi-p-hidroxi-benzóico;    feofitina A;   

DOI  :  10.1590/S0102-695X2008000100011

来源: SciELO

【 摘 要 】

Amongst the different forms of therapy to prevent and cure illnesses, plants have been, undoubtedly, the most utilized ones since the beginning of mankind. Brazil has a great diversity on plants that possess non-researched medicinal potential and are promising sources of therapeutic and pharmacological innovations. The Rubiaceae family is considered the biggest one of the order Gentianales, presenting around 637 genera and 10,700 species. Richardia grandiflora (Cham. & Schltdl.) Steud., known popularly as "ervanço", "poaia" or "ipeca-mirim", has ethnopharmacological indications to use as decoction against hemorrhoids and as vermifuge. Aiming at contributing to the chemotaxonomic study of the family Rubiaceae and considering the absence of data in literature about the chemical constitution of the species Richardia grandiflora, the latter was submitted to a phytochemical study to isolate its chemical constituents, through usual chromatographic methods, and after identifying them by means of spectroscopic methods such as ¹H and 13C NMR, with the add of two-dimensional techniques, besides comparison with literature data. Five constituents were isolated through this first phytochemical study with R. grandiflora: a mixture of the steroids beta-sitosterol and stigmasterol, o-hydroxy-benzoic acid, m-methoxy-p-hydroxy-benzoic acid and phaeophitin A, all of them isolated for the first time from the genus Richardia.

【 授权许可】

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