Effects of a Low Dose of Fish Oil on Inflammatory Markers of Brazilian HIV-Infected Adults on Antiretroviral Therapy:A Randomized, Parallel, Placebo-Controlled Trial

Nutrients

Patrícia H. C. Rondó¹  Lourdes R. A. V. Lima²  Elizabeth S. Fortuna²  Julicristie M. Oliveira³  John S. Yudkin⁴ 

[1] Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, 01246-904, Brazil;Laboratory of Immunology, Adolfo Lutz Institute, Sao Paulo, 13036-225, Brazil;School of Applied Sciences, University of Campinas, Sao Paulo, 13484-350, Brazil;University College London, London WC1H 0EG, UK;

关键词: HIV infection;    AIDS;    metabolic syndrome;    inflammation;    C reactive protein;    fibrinogen;    factor VIII;    interleukin 6;    interleukin 1-beta;    tumor necrosis factor-alpha;   

DOI  :  10.3390/nu7085294

来源: DOAJ

【 摘 要 】

Background: The benefits of antiretroviral therapy for HIV-infected subjects have been limited by an increased risk of metabolic and cardiovascular diseases.The objective of this study was to assess the effects of a low dose of marine omega-3 fatty acids on inflammatory marker concentrations in HIV-infected subjects under antiretroviral therapy (ART). Methods: This was a randomized, parallel, placebo-controlled trial that investigated the effects of 3 g fish oil/day (540 mg of eicosapentaenoic acid—EPA plus 360 mg of docosahexaenoic acid—DHA) or 3 g soy oil/day (placebo) for 24 weeks in83 male and non-pregnant female HIV-infected adults on ART. Results: There were no differences between groups for the measures at baseline. Multilevel analyses revealed no statistically significant relationship between the longitudinal changes in high sensitivity-C reactive protein (hs-CRP) (Wald Chi2 = 0.17, p = 0.918), fibrinogen (Wald Chi2 = 3.82,p = 0.148), and factor VIII (Wald Chi2 = 5.25, p = 0.073) with fish oil. No significant changes in interleukin-6 (IL6), interleukin-1 beta (IL1-beta) and tumor necrosisfactor-alpha (TNF-alpha) serum concentrations were observed with fish oil supplements for 12 weeks. Conclusions: Compared to placebo, a low dose of 900 mg omega-3 fatty acids (EPA plus DHA) in fish oil capsules did not change hs-CRP, fibrinogen, factor VIII, IL6, IL1-beta and TNF-alpha serum concentrations in HIV-infected subjects on ART. Further investigations should consider the assessment of more sensitive inflammatory markers or higher doses to evaluate the effects of marine omega-3 fatty acids in this population. Registered at the Nederlands Trial Register, Identifier no. NTR1798.

【 授权许可】

Unknown