BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants

International Journal of Molecular Sciences

Jing Guo¹  Limin Wei²  Jianfeng Wang²  Gang Wu²  Jingsong Liu² 

[1] Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA),Research Institute MOVE, VU University Amsterdam and University of Amsterdam,Amsterdam 1081LA, The Netherlands;School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China;

关键词: bone morphogenetic protein;    coating;    orthopaedic implant;    osteogenesis;   

DOI  :  10.3390/ijms150610150

来源: DOAJ

【 摘 要 】

The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials;have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy.In this review; we summarise the current knowledge and recent advances regarding BMP-functionalised coatings for orthopaedic implants.

【 授权许可】

Unknown