BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants

International Journal of Molecular Sciences

Jianfeng Wang²  Jing Guo¹  Jingsong Liu²  Limin Wei² 

[1] Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, VU University Amsterdam and University of Amsterdam, Amsterdam 1081LA, The Netherlands; E-Mail:;School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China; E-Mails:

关键词: bone morphogenetic protein;    coating;    orthopaedic implant;    osteogenesis;   

DOI  :  10.3390/ijms150610150

来源: mdpi

【 摘 要 】

The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regardingBMP-functionalised coatings for orthopaedic implants.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.