International Journal of Molecular Sciences | |
BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants | |
Jianfeng Wang2  Jing Guo1  Jingsong Liu2  Limin Wei2  | |
[1] Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, VU University Amsterdam and University of Amsterdam, Amsterdam 1081LA, The Netherlands; E-Mail:;School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China; E-Mails: | |
关键词: bone morphogenetic protein; coating; orthopaedic implant; osteogenesis; | |
DOI : 10.3390/ijms150610150 | |
来源: mdpi | |
【 摘 要 】
The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regardingBMP-functionalised coatings for orthopaedic implants.
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190025336ZK.pdf | 1228KB | download |