The Seroprevalance of Epstein-Barr Virus (EBV) in Children Aged Between 1-18 and Applied to Medical Hospital of Inonu University

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Latife ABUT İŞERݹ  Gülay YETKİN²  Selma AY²  Mehmet Sait TEKEREKOĞLU² 

[1]Kırıkkale Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, KIRIKKALE

[2]İnönü Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, MALATYA

关键词: Epstein-Barr virus;    ELISA;    Antibody response;   

DOI  :  

来源: DOAJ

【 摘 要 】

Epstein-Barr Virus (EBV) has been shown to be the cause of infectious mononucleosis (IM) and has been proved in association with several malignant diseases. EBV infection during infancy and early childhood is mild or subclinical generally, but 50 to 75% of primary infections in young adults may be associated with classical IM. The aim of this study was determine the seroprevalance of EBV specific antigens in children aged 1-18 years and submitted to Medical Hospital of Inönü University and the rate of infection in different age groups. In this respect 660 sera samples were examined for anti-EBV-VCA IgG, IgM and anti-EBNA-1 IgG antibodies by Enzyme-Linked Immunosorbent Assay (ELISA) and 603 (91.3%) specimens were found positive. In patients that admitted to hospital the seropositivity of EBV was 45.1, 85.7, 89.8, 91.2, 96, 96.7 and 96.9 percent at the age range of 1-2 years old, 3-5, 6-8, 9-11,12-14,15-17 and over 18 years of age, respectively. It is obvious that most children had been infected by EBV in early childhood especially from 3 to 5 years of age. The seroprevalance of EBV infection increased with the advancing age and reached 96 percent in the adolescence group.

【 授权许可】

Unknown