Melanin-Like Nanomedicine in Photothermal Therapy Applications

International Journal of Molecular Sciences

Yale Yue¹  Xiao Zhao¹ 

[1] School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China;

关键词: photothermal therapy;    melanin-like nanoparticles;    biocompatibility;    photothermal conversion ability;    tumor;    bioimaging;   

DOI  :  10.3390/ijms22010399

来源: DOAJ

【 摘 要 】

Photothermal therapy (PTT) mediated by nanomaterial has become an attractive tumor treatment method due to its obvious advantages. Among various nanomaterials, melanin-like nanoparticles with nature biocompatibility and photothermal conversion properties have attracted more and more attention. Melanin is a natural biological macromolecule widely distributed in the body and displays many fascinating physicochemical properties such as excellent biocompatibility and prominent photothermal conversion ability. Due to the similar properties, Melanin-like nanoparticles have been extensively studied and become promising candidates for clinical application. In this review, we give a comprehensive introduction to the recent advancements of melanin-like nanoparticles in the field of photothermal therapy in the past decade. In this review, the synthesis pathway, internal mechanism and basic physical and chemical properties of melanin-like nanomaterials are systematically classified and evaluated. It also summarizes the application of melanin-like nanoparticles in bioimaging and tumor photothermal therapy (PTT)in detail and discussed the challenges they faced in clinical translation rationally. Overall, melanin-like nanoparticles still have significant room for development in the field of biomedicine and are expected to applied in clinical PTT in the future.

【 授权许可】

Unknown