Anti-inflammatory and antimicrobial activities of the successive extracts of the aerial parts of Rumex pictus Forssk. growing in Egypt

Journal of HerbMed Pharmacology

Maysa Elsayed Moharam¹  Sherweit Hamed El-Ahmady²  Lamiaa Taha Abou El-Kassem³  Enaam Mohamed AbouZeid³  Nagwa Mohamed Ammar³  Nahla AbdelHamid Ayoub⁴ 

[1] Department of Microbial Chemistry, National Research Centre, Cairo, Egypt;Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt;Department of Pharmacognosy, National Research Centre, Cairo, Egypt;Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia;

关键词: rumex pictus;    phenolic compounds;    anti-inflammatory activity;    antimicrobial activity;   

DOI  :  10.34172/jhp.2021.12

来源: DOAJ

【 摘 要 】

Introduction: Rumex spp. have been used in folk medicine either as food or as medicine for the treatment of several diseases including constipation, fever, inflammation, bacterial and fungal infections. This study aimed to evaluate the anti-inflammatory and antimicrobial activities of the successive extracts of the aerial parts of Rumex pictus Forssk. growing in Egypt, and to identify the chemical constituents in the bioactive extract. Methods: Ether, chloroformic, and 70% methanolic extracts of the aerial parts of R. pictus were assayed for their in vivo anti-inflammatory activity using carrageenan-induced rat hind paw edema method. These extracts were also tested for their in vitro antibacterial and antifungal activities using disc diffusion method. Results: The 70% methanolic extract of R. pictus exhibited significant anti-inflammatory, antibacterial, and anti-candida activities. Thus, fractionation of the bioactive extract was performed which led to the isolation of three anthraquinones, as well as, seven flavonoids. Conclusion: Rumex pictus possesses anti-inflammatory and antimicrobial activities which reinforce its use in ethnomedicine.

【 授权许可】

Unknown