Polyphenols from Passiflora ligularis Regulate Inflammatory Markers and Weight Gain

Biomolecular Concepts

Carmona-Hernandez Juan Carlos¹  Gonzalez-Correa Clara Helena²  Angel-Isaza Jaime²  Narváez-Solarte William² 

[1] Grupo de Investigacion Medica, Universidad de Manizales, Manizales, Colombia;Research Group on Nutrition, Metabolism and Food Security, Universidad de Caldas, Manizales, Colombia;

关键词: passiflora ligularis (granadilla);    phenolic compounds;    anti-inflammatory activity;    overweight rats;   

DOI  :  10.1515/bmc-2021-0005

来源: DOAJ

【 摘 要 】

Weight-related disorders affect more than half of the adult population worldwide; they are also concomitant with a state of chronic low-grade inflammation manifesting in abnormal cytokine production. The present study evaluated the effect of polyphenol and flavonoid extract from Passiflora ligularis (granadilla) on low-grade inflammation and body weight in overweight Wistar rats. To induce weight-gain, rats were fed a chow diet with 30% sucrose water and supplemented with 2.0, 2.5, and 3.0 g/L polyphenol extracts (n = 16). The design was a 3 +1 factorial model performed for 42 days (granadilla polyphenols, 3 levels of supplementation, and 1 control group). In addition to total polyphenol and total flavonoid content, the major identified and quantified polyphenol, via UHPLC, was ferulic acid. Interleukin 6 (IL-6), and cytokine tumor necrosis factor-alpha (TNF-α) were evaluated in serum. A decline in the concentration of TNF-α and in weight-gain was found in P. ligularis (granadilla) groups treated with the 2.5 g/L dose. Consumption of polyphenol extracts from granadilla inhibits interleukin-activity as an indicator of inflammation and aids in body-weight control, considering similar food intake, in overweight Wistar rats.

【 授权许可】

Unknown