Short-Chain Fatty Acids in Chronic Kidney Disease: Focus on Inflammation and Oxidative Stress Regulation

International Journal of Molecular Sciences

August Heidland¹  Pasquale Mone²  Giorgia Magliocca³  Stefania Marzocco³  Biagio Raffaele Di Iorio⁴ 

[1] Department of Internal Medicine and KfH Kidney Center, University of Würzburg, KfH Kidney Center Würzburg, 97080 Würzburg, Germany;Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, NY 10461, USA;Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy;UOC Nephrology AORN “San Giuseppe Moscati”, C.da Amoretta, 83100 Avellino, Italy;

关键词: chronic kidney disease;    short-chain fatty acids;    oxidative stress;    inflammation;    uremic toxins;   

DOI  :  10.3390/ijms23105354

来源: DOAJ

【 摘 要 】

Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary complications that increase comorbidity and mortality. In patients with CKD, there is a significant qualitative and quantitative alteration in the gut microbiota, which, consequently, also leads to reduced production of beneficial bacterial metabolites, such as short-chain fatty acids. Evidence supports the beneficial effects of short-chain fatty acids in modulating inflammation and oxidative stress, which are implicated in CKD pathogenesis and progression. Therefore, this review will provide an overview of the current knowledge, based on pre-clinical and clinical evidence, on the effect of SCFAs on CKD-associated inflammation and oxidative stress.

【 授权许可】

Unknown