The antioxidant α-lipoic acid attenuates intermittent hypoxia-related renal injury in a mouse model of sleep apnea

Sleep

Badran, Mohammad^2¹  Abuyassin, Bisher^1² 

[1] Departments of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada^2;Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada^1

关键词: obstructive sleep apnea;    chronic kidney disease;    oxidative stress;    inflammation;    antioxidant;   

DOI  :  10.1093/sleep/zsz066

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesOxidative stress and inflammation are proposed to mediate kidney diseases that occur in patients with obstructive sleep apnea (OSA). We examined the hypothesis that α-lipoic acid (LA) prevents renal injury in a mouse model of sleep apnea.

【 授权许可】

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