The Impact of Oxidative Stress in Male Infertility

Frontiers in Molecular Biosciences

Maria Elisabetta Coccia¹  Claudia Fiorillo²  Amanda Mannucci²  Flavia Rita Argento²  Matteo Becatti²  Niccolò Taddei²  Eleonora Fini² 

[1] Assisted Reproductive Technology Centre, Careggi Hospital, University of Florence, Florence, Italy;Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy;

关键词: oxidative stress;    ROS;    reactive oxygen species;    male infertility;    spermatozoa;    semen parameters;   

DOI  :  10.3389/fmolb.2021.799294

来源: DOAJ

【 摘 要 】

At present infertility is affecting about 15% of couples and male factor is responsible for almost 50% of infertility cases. Oxidative stress, due to enhanced Reactive Oxygen Species (ROS) production and/or decreased antioxidants, has been repeatedly suggested as a new emerging causative factor of this condition. However, the central roles exerted by ROS in sperm physiology cannot be neglected. On these bases, the present review is focused on illustrating both the role of ROS in male infertility and their main sources of production. Oxidative stress assessment, the clinical use of redox biomarkers and the treatment of oxidative stress-related male infertility are also discussed.

【 授权许可】

Unknown