ОКИСЛИТЕЛЬНЫЙ СТРЕСС И МУЖСКАЯ ФЕРТИЛЬНОСТЬ: СОВРЕМЕННЫЙ ВЗГЛЯД НА ПРОБЛЕМУ

Acta Biomedica Scientifica

Елена Анатольевна Кириленко¹  Виктор Фёдорович Онопко¹ 

[1] ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России

关键词: окислительный стресс;    активные формы кислорода;    мужская инфертильность;    антиоксидант;    oxidative stress;    reactive oxygen species;    male infertility;    antioxidant;   

DOI  :  10.12737/article_59a614fd84d146.40261567

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Presently, the expressed tendency to deterioration in parameters of semen is noted in the world, at the same time both the quantity of spermatozoa, and their functional properties decrease. The spermatogenesis is a difficult, extremely sensible process of cellular differentiation; the different systems of organism participate in its adjusting. Violations in any links affect the process of spermatogenesis, and finally, affects parameters of semen. This systematic review of the literature analyses recent publications concerning studies of oxidative stress influencing male fertility. The oxidative stress - the very widespread version of pathology, which accompanies and/or is one of key mechanisms in development of many types of reproductive disorders in men. There are three main mechanisms of impaired fertile function of men in the development of oxidative stress: reducing sperm motility, violation of ability of spermatozoa to penetrate into oocyte and spermatozoa DNA damage. The factors promoting its development are numerous: environmental pollution, life style, addictions, stress, diabetes, and varicocele; however, the most frequent reason of development of oxidative stress in reproductive system of men are infectious and inflammatory diseases and antispermal autoimmune processes in a man's urogenital tract. Considering possible participation of free-radical processes in patospermia development, it is worthwhile to use antioxidants in all cases of the man's infertility connected with oxidative stress.

【 授权许可】

CC BY