Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons

Brain Sciences

Nadezda V. Andrianova¹  Ljubava D. Zorova¹  Valentina A. Babenko¹  Savva D. Zorov¹  Irina B. Pevzner¹  Dmitry B. Zorov¹  Vasily A. Popkov¹  Denis N. Silachev¹  Egor Yu. Plotnikov¹  Gennady T. Sukhikh² 

[1] Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia;Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, 117997 Moscow, Russia;

关键词: neuroprotection;    brain;    mitochondria;    uncoupling;   

DOI  :  10.3390/brainsci11081050

来源: DOAJ

【 摘 要 】

There has been an explosion of interest in the use of uncouplers of oxidative phosphorylation in mitochondria in the treatment of several pathologies, including neurological ones. In this review, we analyzed all the mechanisms associated with mitochondrial uncoupling and the metabolic and signaling cascades triggered by uncouplers. We provide a full set of positive and negative effects that should be taken into account when using uncouplers in experiments and clinical practice.

【 授权许可】

Unknown