Identification of the brain networks that contribute to the interaction between physical function and working memory: An fMRI investigation with over 1,000 healthy adults

NeuroImage

Atsushi Miyazaki¹  Tetsuya Matsuda²  Toru Ishihara²  Hiroki Tanaka² 

[1] Japan Society for the Promotion of Science, Tokyo, Japan;Tamagawa University Brain Science Institute, Tokyo, Japan;

关键词: Cardiorespiratory fitness;    Cognitive control;    Dorsolateral prefrontal cortex;    Default mode network;    Frontoparietal network;    Hand dexterity;   

DOI  :  

来源: DOAJ

【 摘 要 】

There is a growing consensus regarding the positive relationship between physical function and working memory; however, explanations of task-evoked functional activity regarding this relationship and its differences in physical function domains remain controversial. This study illustrates the cross-sectional relationships between cardiorespiratory fitness, gait speed, hand dexterity, and muscular strength with working memory task (N-back task) performance and the mediating effects of task-evoked functional activity in 1033 adults aged between 22 and 37 years. The results showed that cardiorespiratory fitness and hand dexterity were independently associated with N-back task performance to a greater extent and in contrast to gait speed and muscular strength. These relationships were mediated by task-evoked functional activity in a part of the frontoparietal network (FPN) and default mode network (DMN). Superior cardiorespiratory fitness could contribute to working memory performance by enhancing the compensational role of FPN-related broader region activation. Hand dexterity was associated with moderation of the interaction in terms of task-evoked activation between the FPN and DMN, which in turn, improved N-back task performance. Based on these findings, we conclude that cardiorespiratory fitness and hand dexterity have common and unique mechanisms enhancing working memory.

【 授权许可】

Unknown