Nicotine and networks: Potential for enhancement of mood and cognition in late-life depression

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:84

Review

Gandelman, Jason A.¹  Newhouse, Paul^2,3  Taylor, Warren D.^2,3 

[1] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Med Ctr, Dept Psychiat, Ctr Cognit Med, Nashville, TN 37212 USA

[3] Tennessee Valley Healthcare Syst, Dept Vet Affairs, Med Ctr, Geriatr Res Educ & Clin Ctr, Nashville, TN 37212 USA

关键词: Depression;    Depressive disorder;    Aging;    Geriatrics;    Nicotine;    Nicotinic receptor;    Cognition;    Cognitive impairment;    Acetylcholine;    Antidepressant;    Review;    Attention;    Memory;    Default mode network;    Intrinsic network;    Cognitive control;    Executive control;    Experimental therapeutics;   

DOI  :  10.1016/j.neubiorev.2017.08.018

来源: Elsevier

【 摘 要 】

Late-life depression is characterized by both lower mood and poor cognitive performance, symptoms that often do not fully respond to current antidepressant medications. Nicotinic acetylcholine receptor (nAChR) agonists such as nicotine may serve as a novel therapeutic approach for this population. Both preclinical and preliminary clinical studies suggest that nAChR agonists can improve depressive behavior in animal models and improve mood in depressed individuals. Substantial literature also supports that nAChR agonists benefit cognitive performance, particularly in older populations. These potential benefits may be mediated by the effects of nAChR stimulation on neural network function and connectivity. Functional neuroimaging studies detail effects of nAChR agonists on the default mode network, central-executive network, and salience network that may oppose or reverse network changes seen in depression. We propose that, given the existent literature and the clinical presentation of late-life depression, nicotine or other nAChR agonists may have unique therapeutic benefits in this population and that clinical trials examining nicotine effects on mood, cognition, and network dynamics in late-life depression are justified.

【 授权许可】

Free