Histo-epidemiological profile of breast cancers among women in the Central African Republic: about 174 cases

BMC Cancer

Ping Yin¹  Chang Shu¹  Minghui Yin¹  Tingting Qing¹  Augustin Balekouzou¹  Sylvain Wilfrid Nambei²  Boniface Koffi³  Christian Maucler Pamatika³  Cavin Epi Bekolo⁴  Marceline Djeintote⁵  Dieubeni Rawago Mandjiza⁵  Bertrand Ba-Mpoutou⁵ 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College of Huazhong University of Sciences and Technology;Faculty of Health Sciences, University of Bangui;Hospital Laboratory Friendship Bangui;Ministry of Public Health, Central Medical d’Arrondissement de Bare;National Laboratory of Clinical Biology and Public Health;

关键词: Breast cancer;    Women;    Epidemiology;    Histology;    Central African Republic;   

DOI  :  10.1186/s12885-018-4256-2

来源: DOAJ

【 摘 要 】

Abstract Background Breast cancer (BC) is the most common cancer in women worldwide and leading cause of cancer deaths indeveloping countries. There is very limited data on BC in the Central African Republic. The purpose of this study was to describe the epidemiological and histopathological characteristics of BC in Bangui. Methods This retrospective study reviewed cancer data registries and medical records from the Pathology Unit of the National Laboratory in Bangui and the General Surgery and Gyneacology service from 2003 to 2015. A questionnaire was designed to collect information and data was analysed using descriptive and inferential statistical methods. Results In total, 174 cases of BC were recorded, with an average annual frequency of13.4 cases per year. The age of the women at diagnosis varied from 16 to 90 years with a median of 45.5 years and InterQuartile range (IQR) 18 years. The age group of 45–54 years represented the majority of the study population (n = 51, 29.3%).About 25.9%ofthe patients were non-educated and 85.6% lived in cities. Over 48 % of the women were housewives with a moderate economic status (n = 99, 56.9%). Sixty nine percent of the specimens received at the pathology unit were pieces of breast tumour. Invasive ductal carcinoma (n = 113, 64.9%) was the main histological form and most of the tumours were of Grade III (n = 14, 46.7%). The only imaging assessment was ultrasound performed in (n = 53, 30.4%) women. Surgery was performed in (n = 166, 95.4%) patients, while (n = 159, 91.4%) received complementary chemotherapy. At the end of the study, 84.5%of the cases had died, 12.1% were alive and 3.4% were considered “lost to follow-up”. Conclusion BC is an important public health problem and affected most of the younger Central African women. Epidemiological and histological characteristics are more or less common to those described other developing countries. It is imperative to improve the awareness of health care institutions and women on the burden of BC, to carry out early screening of BC, and to strengthen the capacity of women’s health care system.

【 授权许可】

Unknown