Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas

Radiologia Brasileira

Almir Galvão Vieira Bitencourt¹  Eduardo Nóbrega Pereira Lima¹  Rubens Chojniak¹  Elvira Ferreira Marques¹  Juliana Alves De Souza¹  Luciana Graziano¹  Wesley Pereira Andrade¹  Cynthia Aparecida Bueno De Toledo Osório¹ 

关键词: Breast cancer;    PET/CT;    Histology;    Neoplasias da mama;    PET/CT;    Histologia;   

DOI  :  10.1590/S0100-39842014000200006

来源: SciELO

【 摘 要 】

Objective To correlate the results of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) performed with a specific protocol for assessment of breasts with histological/immunohistochemical findings in breast carcinoma patients. Materials and Methods Cross-sectional study with prospective data collection, where patients with biopsy-confirmed breast carcinomas were studied. The patients underwent PET/CT examination in prone position, with a specific protocol for assessment of breasts. PET/CT findings were compared with histological and immunohistochemical data. Results The authors identified 59 malignant breast lesions in 50 patients. The maximum diameter of the lesions ranged from 6 to 80 mm (mean: 32.2 mm). Invasive ductal carcinoma was the most common histological type (n = 47; 79.7%). At PET/CT, 53 (89.8%) of the lesions demonstrated anomalous concentrations of 18F-FDG, with maximum SUV ranging from 0.8 to 23.1 (mean: 5.5). A statistically significant association was observed between higher values of maximum SUV and histological type, histological grade, molecular subtype, tumor diameter, mitotic index and Ki-67 expression. Conclusion PET/CT performed with specific protocol for assessment of breasts has demonstrated good sensitivity and was associated with relevant histological/immunohistochemical factors related to aggressiveness and prognosis of breast carcinomas.

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