Myeloid-derived suppressor cells in bacterial infections

Frontiers in Cellular and Infection Microbiology

Nikolaus eRieber¹  Andreas ePeschel²  Michael eOst³  Anurag eSingh³  Roman eMehling³  Dominik eHartl³ 

[1] Department of Pediatrics, Kinderklinik München Schwabing, Klinikum Schwabing, StKM GmbH und Klinikum rechts der Isar, Technische Universität München, Munich, Germany;Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology Dept., University of Tübingen, Tübingen, Germany;University of Tübingen;

关键词: Bacteria;    Infection;    Sepsis;    immune suppression;    myeloid-derived suppressor cells;    MDSC;   

DOI  :  10.3389/fcimb.2016.00037

来源: DOAJ

【 摘 要 】

Myeloid-derived suppressor cells (MDSCs) comprise monocytic and granulocytic innate immune cells with the capability of suppressing T- and NK-cell responses. While the role of MDSCs has been studied in depth in malignant diseases, the understanding of their regulation and function in infectious disease conditions has just begun to evolve. Here we summarize and discuss the current view how MDSCs participate in bacterial infections and how this knowledge could be exploited for potential future therapeutics.

【 授权许可】

Unknown